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             Discussion and screenshots:http://www.zabbix.com/forum/showthread.php?t=13198 
I have my Zabbix queue ( zabbix[queue] ) around 750 all the time, however, If I go to Administration -> Queue I only have 39 from 2 hosts that currently offline (see screen). Everything seems to work meanwhile 
Also: Everytime I add new host, zabbix[queue] rises a bit : example , from 750 to 780) 
zabbix_server conf: 
	- This is config file for ZABBIX server process
 
	- To get more information about ZABBIX,
 
	- go http://www.zabbix.com
 
 
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												- GENERAL PARAMETERS #################
 
											 
											 
										 
										 
									 
									 
								 
								 
							 
							 
						 
						 
					 
					 
				 
				 
			 
			 
		 
		 
	 
	 
 
	- This defines unique NodeID in distributed setup,
 
	- Default value 0 (standalone server)
 
	- This parameter must be between 0 and 999
 
#NodeID=0 
 
	- Number of pre-forked instances of pollers
 
	- Default value is 5
 
	- This parameter must be between 0 and 255
 
StartPollers=5 
 
	- Number of pre-forked instances of IPMI pollers
 
	- Default value is 0
 
	- This parameter must be between 0 and 255
 
#StartIPMIPollers=0 
 
	- Number of pre-forked instances of pollers for unreachable hosts
 
	- Default value is 1
 
	- This parameter must be between 0 and 255
 
#StartPollersUnreachable=1 
 
	- Number of pre-forked instances of trappers
 
	- Default value is 5
 
	- This parameter must be between 0 and 255
 
StartTrappers=5 
 
	- Number of pre-forked instances of ICMP pingers
 
	- Default value is 1
 
	- This parameter must be between 0 and 255
 
#StartPingers=1 
 
	- Number of pre-forked instances of discoverers
 
	- Default value is 1
 
	- This parameter must be between 0 and 255
 
#StartDiscoverers=1 
 
	- Number of pre-forked instances of HTTP pollers
 
	- Default value is 1
 
	- This parameter must be between 0 and 255
 
#StartHTTPPollers=1 
 
	- Listen port for trapper. Default port number is 10051. This parameter
 
	- must be between 1024 and 32767
 
 
#ListenPort=10051 
	- Source IP address for outgoing connections
 
#SourceIP= 
 
	- Listen interface for trapper. Trapper will listen on all network interfaces
 
	- if this parameter is missing.
 
 
#ListenIP=127.0.0.1 
	- How often ZABBIX will perform housekeeping procedure
 
	- (in hours)
 
	- Default value is 1 hour
 
	- Housekeeping is removing unnecessary information from
 
	- tables history, alert, and alarms
 
	- This parameter must be between 1 and 24
 
 
#HousekeepingFrequency=1 
	- How often ZABBIX will try to send unsent alerts
 
	- (in seconds)
 
	- Default value is 30 seconds
 
SenderFrequency=30 
 
	- Uncomment this line to disable housekeeping procedure
 
#DisableHousekeeping=1 
 
	- Specifies debug level
 
	- 0 - debug is not created
 
	- 1 - critical information
 
	- 2 - error information
 
	- 3 - warnings (default)
 
	- 4 - for debugging (produces lots of information)
 
 
DebugLevel=4 
	- Specifies how long we wait for agent response (in sec)
 
	- Must be between 1 and 30
 
Timeout=5 
 
	- Specifies how many seconds trapper may spend processing new data
 
	- Must be between 1 and 300
 
#TrapperTimeout=5 
 
	- After how many seconds of unreachability treat a host as unavailable
 
#UnreachablePeriod=45 
 
	- How often check host for availability during the unavailability period
 
#UnavailableDelay=60 
 
	- Name of PID file
 
 
PidFile=/var/tmp/zabbix_server.pid 
	- Name of log file
 
	- If not set, syslog is used
 
 
LogFile=/tmp/zabbix_server.log 
	- Maximum size of log file in MB. Set to 0 to disable automatic log rotation.
 
#LogFileSize=1 
 
	- Location for custom alert scripts
 
AlertScriptsPath=/home/zabbix/bin/ 
 
	- Location of external scripts
 
#ExternalScripts=/etc/zabbix/externalscripts 
 
	- Location of fping. Default is /usr/sbin/fping
 
	- Make sure that fping binary has root permissions and SUID flag set
 
#FpingLocation=/usr/sbin/fping 
 
	- Location of fping6. Default is /usr/sbin/fping6
 
	- Make sure that fping binary has root permissions and SUID flag set
 
#Fping6Location=/usr/sbin/fping6 
 
	- Temporary directory. Default is /tmp
 
#TmpDir=/tmp 
 
	- Frequency of ICMP pings (item keys 'icmpping' and 'icmppingsec'). Default is 60 seconds.
 
#PingerFrequency=60 
 
	- Database host name
 
	- Default is localhost
 
 
#DBHost=localhost 
	- Database name
 
	- SQLite3 note: path to database file must be provided. DBUser and DBPassword are ignored.
 
DBName=zabbix 
 
	- Database user
 
 
DBUser=zabbix 
	- Connect to MySQL using Unix socket?
 
 
#DBSocket=/tmp/mysql.sock 
#PERFORMANCE OPT 
StartDBSyncers=1  
             
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