we are having huge performance issue with Zabbix Server. we are monitoring 1000+ agent with three proxys.
on main server(where we facing this performance issue) we have zabbix server and one proxy running with there databases containers.

Infra Description of server where we facing this issue:
Zabbix server + one proxy + DBs containers running on m4.2xlarge instance (8cpu(2.4GHz)/32gb Mem)

ZabbixServer:
StartTrappers=35
CacheSize=160M
ValueCacheSize=80M
MaxHousekeeperDelete=1000
StartDBSyncers=10
StartEscalators=5
StartHTTPPollers=5
StartPingers=0
TrendCacheSize=160M

Zabbix server DB(postgres) :

max_connections=100
autovacuum_vacuum_threshold=50
autovacuum_vacuum_scale_factor=0.01
autovacuum_vacuum_cost_delay=20ms
autovacuum_vacuum_cost_limit=3000
autovacuum_max_workers=6
maintenance_work_mem=8GB
max_parallel_workers_per_gather=4
max_worker_processes=16
effective_io_concurrency=4
synchronous_commit=off
random_page_cost=1.1
shared_buffers=256MB'
huge_pages=try'
autovacuum_analyze_threshold=200
autovacuum_analyze_scale_factor=0.01
work_mem=150MB'

After starting containers with above parameters, we are getting performance issue. load average is very huge on zabbix server and DB containers.
Can anyone please help us in tuning.