On 3 servers when I ran the MSI the installation failed with no error other than ended "prematurely" and was rolled back.  I enabled logging via the command line and they all reported this:

[lines above truncated]
Action start 0:43:11: InstallFinalize.
TemplateFiles_Deferred: MSI Extensions 1.5.918.0
TemplateFiles_Deferred: C:\Program Files\Zabbix Agent\zabbix_agentd.conf => C:\Program Files\Zabbix Agent\zabbix_agentd.conf
ExecFirewallExceptions:  Installing firewall exception2 Zabbix Agent listen port on port 10050, protocol 6
ExecFirewallExceptions:  Error 0x800706d9: failed trying to find existing port rule
ExecFirewallExceptions:  Error 0x800706d9: failed to add/update port exception for name 'Zabbix Agent listen port' on port 10050, protocol 6
Action ended 0:43:12: InstallFinalize. Return value 3.
ExecFirewallExceptions:  Uninstalling firewall exception2 Zabbix Agent listen port on port 10050, protocol 6
ExecFirewallExceptions:  Error 0x800706d9: failed to remove authorized app
ExecFirewallExceptions:  Error 0x800706d9: failed to remove port exception for name 'Zabbix Agent listen port' on port 10050, protocol 6
Action ended 0:43:12: INSTALL. Return value 3.
Action ended 0:43:12: ExecuteAction. Return value 3.
Action start 0:43:12: FatalError.
Action ended 0:43:13: FatalError. Return value 2.
Action ended 0:43:13: INSTALL. Return value 3.
=== Logging stopped: 4/24/2019  0:43:13 ===
MSI (c) (1C:C0) [00:43:13:087]: Product: Zabbix Agent (64-bit) – Installation failed.

MSI (c) (1C:C0) [00:43:13:102]: Windows Installer installed the product. Product Name: Zabbix Agent (64-bit). Product Version: 4.2.1.92832. Product Language: 1033. Installation success or error status: 1603.

Each of these servers are windows server 2008.  Two of them are "R2" and one is just standard.  I have installed it fine on many other 2008/R2s and also on 2016's no problem.