Duplicate key errors inserting to items_applications

Steps to reproduce:

1. Clean install of OS and Zabbix
2. Verify database and all tables are configured with CHARACTER SET utf8 COLLATE utf8_bin;
3. Configure a few OS hosts for monitoring using the OS agent (windows)

1. Configure a few network devices (routers, wifi) for monitoring via SNMP
2. Configure zabbix agentd on the zabbix server
3. Verify functionality and monitoring data is being collected
4. Monitor contents of zabbix_server.log

Result:
Observe many/repeating occurrences of messages similar to:

 1753:20191127:071745.921 [Z3005] query failed: [1062] Duplicate entry '1346-30464' for key 'items_applications_1' [insert into items_applications (itemappid,applicationid,itemid) values (45487,1346,30464),(45488,1347,30480),(45489,1343,30471),(45490,1347,30470),(45491,1343,30466),(45492,1345,30463),(45493,1344,30472),(45494,1344,30467),(45495,1347,30465),(45496,1346,30479),(45497,1346,30469),(45498,1343,30461),(45499,1347,30475),(45500,1344,30462),(45501,1345,30473),(45502,1344,30477),(45503,1345,30478),(45504,1345,30468),(45505,1346,30474),(45506,1343,30476);
Expected:
No messages.

Questions:

Please explain the function and use of the items_applications table, how these messages may be affecting zabbix, and if possible how I might correct what's causing them.