Steps to reproduce:

1. Create an item with 2 interfaces
2. Create 2 items, one that is retrieved on interface #1, the other item is retrieved from interface #2
3. The item has to be an HTTP Agent and the item to be obtained has to be referenced using the {HOST.IP} macro
4. {Host.IP}

   and data retrieved works fine on both interfaces #1,#2 with TEST  button

5. Then when the device is left to be updated by zabbix, {HOST.IP} is resolved only to interface #1
6. Using {HOST.IP2} with interface #2 only gives an error

I will upload images of the item setup for the interface #2 as the #1 works fine always

Interface #1 has data 1080, interface #2 has data 0080

Result for interface #2:
**

If clicking int est, {HOST.IP} is solved as 192.168.16.16 which is fine, and retrieves the data 0080 which is the correct one

I click in add the item and then once the data is refreshed, it gets the data from 192.168.16.15 (interface #1)

If i explicitly define the item to be retrieved from the fixed IP. then the result is ok always -> 0080

Here the summary of the data retrieved by {HOST.IP} pointing to the 2nd interface, and pointing the 2nd interface but with the explicit Ip in the http path