https://git.zabbix.com/projects/ZBX/repos/zabbix/browse/templates/app/nutanix_http?at=release/7.0
It says that the macros (4 in total) may be set on, quote: "on the host or template level"

The solution consists of 3 templates, where one is main ("Nutanix Prism Element by HTTP") and 2 are used for host prototypes.
Its ok if you set the 4 macros on all the 3 templates, while this is not stated cleanly on the doc.

But if you set the macros only to a main host you created, then LLD discovered hosts do not get the macro value in any way.
So LLD discovered hosts will fail with error "Required param is not set: password." as they do not have the macros.

This solution may require rework or significant improvement in the doc how it should be used.