"expression tree is too large (maximum depth 1000)" error logged to zabbix_proxy log. configuration is not updated

I've run into an issue that occurs in a large environment. I have 3 proxies that each have 1162 hosts. If the hosts that are assigned to those proxies are radically changed (maybe all hosts switch proxies), then the proxies are not able to reload their configuration cache. The proxy logs get this error when they try:

edit:
moved to first comment bellow