Our Zabbix server logs indicate something like this :

38568:20131107:101659.543 item [500260fb-395f-c727-b8ea-7072f8784cb1:vmware.vm.vfs.dev.write[{$URL},

,scsi0:0,ops]] became not supported: Simple check is not supported
However it currently is impossible to search for host "500260fb-395f-c727-b8ea-7072f8784cb1" using the frontend - this should be fixed before 2.2 goes final.

I know that there are ZBXNEXT requests for this but since VMware discovery in 2.2 heavily relies upon UUID style hostnames I think this should be classified as a bug and not a feature request.