I have SNMP items with dynamic indexes in Zabbix 2.0.2
SNMP OID "[index,ifDescr,XGigabitEthernet3/0/4]"

snmpwalk from zabbix server:

1. snmpwalk -v2c -c xxxxx 10.2.0.12 ifDescr
   IF-MIB::ifDescr.1 = STRING: InLoopBack0
   IF-MIB::ifDescr.2 = STRING: NULL0
   IF-MIB::ifDescr.3 = STRING: Console0/0/0
   IF-MIB::ifDescr.4 = STRING: Ethernet0/0/0
   IF-MIB::ifDescr.5 = STRING: Console0/0/1
   IF-MIB::ifDescr.6 = STRING: GigabitEthernet1/0/0
   IF-MIB::ifDescr.7 = STRING: GigabitEthernet1/0/1
   IF-MIB::ifDescr.8 = STRING: GigabitEthernet1/0/2
   IF-MIB::ifDescr.9 = STRING: GigabitEthernet1/0/3
   IF-MIB::ifDescr.10 = STRING: GigabitEthernet1/0/4
   IF-MIB::ifDescr.11 = STRING: GigabitEthernet1/0/5
   IF-MIB::ifDescr.12 = STRING: GigabitEthernet1/0/6
   IF-MIB::ifDescr.13 = STRING: GigabitEthernet1/0/7
   IF-MIB::ifDescr.14 = STRING: GigabitEthernet1/0/8
   IF-MIB::ifDescr.15 = STRING: GigabitEthernet1/0/9
   IF-MIB::ifDescr.16 = STRING: GigabitEthernet1/0/10
   IF-MIB::ifDescr.17 = STRING: GigabitEthernet1/0/11
   IF-MIB::ifDescr.18 = STRING: GigabitEthernet1/0/12
   IF-MIB::ifDescr.19 = STRING: GigabitEthernet1/0/13
   IF-MIB::ifDescr.20 = STRING: GigabitEthernet1/0/14
   IF-MIB::ifDescr.21 = STRING: GigabitEthernet1/0/15
   IF-MIB::ifDescr.22 = STRING: GigabitEthernet1/0/16
   IF-MIB::ifDescr.23 = STRING: GigabitEthernet1/0/17
   IF-MIB::ifDescr.24 = STRING: GigabitEthernet1/0/18
   IF-MIB::ifDescr.25 = STRING: GigabitEthernet1/0/19
   IF-MIB::ifDescr.26 = STRING: GigabitEthernet1/0/20
   IF-MIB::ifDescr.27 = STRING: GigabitEthernet1/0/21
   IF-MIB::ifDescr.28 = STRING: GigabitEthernet1/0/22
   IF-MIB::ifDescr.29 = STRING: GigabitEthernet1/0/23
   IF-MIB::ifDescr.30 = STRING: GigabitEthernet1/0/24
   IF-MIB::ifDescr.31 = STRING: GigabitEthernet1/0/25
   IF-MIB::ifDescr.32 = STRING: GigabitEthernet1/0/26
   IF-MIB::ifDescr.33 = STRING: GigabitEthernet1/0/27
   IF-MIB::ifDescr.34 = STRING: GigabitEthernet1/0/28
   IF-MIB::ifDescr.35 = STRING: GigabitEthernet1/0/29
   IF-MIB::ifDescr.36 = STRING: GigabitEthernet1/0/30
   IF-MIB::ifDescr.37 = STRING: GigabitEthernet1/0/31
   IF-MIB::ifDescr.38 = STRING: GigabitEthernet1/0/32
   IF-MIB::ifDescr.39 = STRING: GigabitEthernet1/0/33
   IF-MIB::ifDescr.40 = STRING: GigabitEthernet1/0/34
   IF-MIB::ifDescr.41 = STRING: GigabitEthernet1/0/35
   IF-MIB::ifDescr.42 = STRING: GigabitEthernet1/0/36
   IF-MIB::ifDescr.43 = STRING: GigabitEthernet1/0/37
   IF-MIB::ifDescr.44 = STRING: GigabitEthernet1/0/38
   IF-MIB::ifDescr.45 = STRING: GigabitEthernet1/0/39
   IF-MIB::ifDescr.46 = STRING: GigabitEthernet1/0/40
   IF-MIB::ifDescr.47 = STRING: GigabitEthernet1/0/41
   IF-MIB::ifDescr.48 = STRING: GigabitEthernet1/0/42
   IF-MIB::ifDescr.49 = STRING: GigabitEthernet1/0/43
   IF-MIB::ifDescr.50 = STRING: GigabitEthernet1/0/44
   IF-MIB::ifDescr.51 = STRING: GigabitEthernet1/0/45
   IF-MIB::ifDescr.52 = STRING: GigabitEthernet1/0/46
   IF-MIB::ifDescr.53 = STRING: GigabitEthernet1/0/47
   IF-MIB::ifDescr.54 = STRING: XGigabitEthernet3/0/0
   IF-MIB::ifDescr.55 = STRING: XGigabitEthernet3/0/1
   IF-MIB::ifDescr.56 = STRING: XGigabitEthernet3/0/2
   IF-MIB::ifDescr.57 = STRING: XGigabitEthernet3/0/3
   IF-MIB::ifDescr.58 = STRING: XGigabitEthernet3/0/4
   IF-MIB::ifDescr.59 = STRING: XGigabitEthernet3/0/5
   IF-MIB::ifDescr.60 = STRING: XGigabitEthernet3/0/6
   IF-MIB::ifDescr.61 = STRING: XGigabitEthernet3/0/7
   IF-MIB::ifDescr.62 = STRING: XGigabitEthernet3/0/8
   IF-MIB::ifDescr.63 = STRING: XGigabitEthernet3/0/9
   IF-MIB::ifDescr.64 = STRING: XGigabitEthernet3/0/10
   IF-MIB::ifDescr.65 = STRING: XGigabitEthernet3/0/11
   IF-MIB::ifDescr.66 = STRING: XGigabitEthernet3/0/12
   IF-MIB::ifDescr.67 = STRING: XGigabitEthernet3/0/13
   IF-MIB::ifDescr.68 = STRING: XGigabitEthernet3/0/14
   IF-MIB::ifDescr.69 = STRING: XGigabitEthernet3/0/15
   IF-MIB::ifDescr.70 = STRING: XGigabitEthernet2/0/0
   IF-MIB::ifDescr.71 = STRING: XGigabitEthernet2/0/1
   IF-MIB::ifDescr.72 = STRING: XGigabitEthernet2/0/2
   IF-MIB::ifDescr.73 = STRING: XGigabitEthernet2/0/3
   IF-MIB::ifDescr.74 = STRING: XGigabitEthernet2/0/4
   IF-MIB::ifDescr.75 = STRING: XGigabitEthernet2/0/5
   IF-MIB::ifDescr.76 = STRING: XGigabitEthernet2/0/6
   IF-MIB::ifDescr.77 = STRING: XGigabitEthernet2/0/7
   IF-MIB::ifDescr.78 = STRING: XGigabitEthernet2/0/8
   IF-MIB::ifDescr.79 = STRING: XGigabitEthernet2/0/9
   IF-MIB::ifDescr.80 = STRING: XGigabitEthernet2/0/10
   IF-MIB::ifDescr.81 = STRING: XGigabitEthernet2/0/11
   IF-MIB::ifDescr.82 = STRING: XGigabitEthernet2/0/12
   IF-MIB::ifDescr.83 = STRING: XGigabitEthernet2/0/13
   IF-MIB::ifDescr.84 = STRING: XGigabitEthernet2/0/14
   IF-MIB::ifDescr.85 = STRING: XGigabitEthernet2/0/15
   IF-MIB::ifDescr.86 = STRING: Vlanif104
   IF-MIB::ifDescr.87 = STRING: Vlanif801
   IF-MIB::ifDescr.88 = STRING: Eth-Trunk0
   IF-MIB::ifDescr.89 = STRING: LoopBack0
   IF-MIB::ifDescr.90 = STRING: Vlanif803
   IF-MIB::ifDescr.91 = STRING: Vlanif802
   IF-MIB::ifDescr.92 = STRING: Vlanif804
   IF-MIB::ifDescr.93 = STRING: Vlanif805
   IF-MIB::ifDescr.94 = STRING: Vlanif806
   IF-MIB::ifDescr.95 = STRING: Vlanif807
   IF-MIB::ifDescr.96 = STRING: Vlanif808
   IF-MIB::ifDescr.97 = STRING: Vlanif801-mpls
   IF-MIB::ifDescr.98 = STRING: Vlanif802-mpls
   IF-MIB::ifDescr.99 = STRING: Vlanif803-mpls
   IF-MIB::ifDescr.100 = STRING: Vlanif804-mpls
   IF-MIB::ifDescr.101 = STRING: Vlanif805-mpls
   IF-MIB::ifDescr.102 = STRING: Vlanif806-mpls
   IF-MIB::ifDescr.103 = STRING: Vlanif807-mpls
   IF-MIB::ifDescr.104 = STRING: Vlanif808-mpls
   IF-MIB::ifDescr.105 = STRING: Eth-Trunk1
   IF-MIB::ifDescr.106 = STRING: Vlanif815
   IF-MIB::ifDescr.118 = STRING: Vlanif33
   IF-MIB::ifDescr.119 = STRING: Vlanif41
   IF-MIB::ifDescr.122 = STRING: Vlanif100
   IF-MIB::ifDescr.123 = STRING: Vlanif300
   IF-MIB::ifDescr.124 = STRING: Vlanif400
   IF-MIB::ifDescr.125 = STRING: Vlanif500
   IF-MIB::ifDescr.127 = STRING: Vlanif32
   IF-MIB::ifDescr.128 = STRING: Vlanif507
   IF-MIB::ifDescr.129 = STRING: Vlanif773
   IF-MIB::ifDescr.130 = STRING: Vlanif24
   IF-MIB::ifDescr.131 = STRING: Vlanif418
   IF-MIB::ifDescr.132 = STRING: Vlanif419
   IF-MIB::ifDescr.133 = STRING: Vlanif420
   IF-MIB::ifDescr.134 = STRING: Vlanif421
   IF-MIB::ifDescr.135 = STRING: Vlanif5
   IF-MIB::ifDescr.136 = STRING: Vlanif254
   IF-MIB::ifDescr.141 = STRING: Vlanif774
   IF-MIB::ifDescr.142 = STRING: Vlanif13
   IF-MIB::ifDescr.143 = STRING: Vlanif779
   IF-MIB::ifDescr.144 = STRING: Vlanif14
   IF-MIB::ifDescr.145 = STRING: Eth-Trunk2
   IF-MIB::ifDescr.146 = STRING: Vlanif108
   IF-MIB::ifDescr.147 = STRING: Vlanif511
   IF-MIB::ifDescr.148 = STRING: Vlanif817

Searching index is 58
IF-MIB::ifDescr.58 = STRING: XGigabitEthernet3/0/4

Snmpget ifHCOutOctets.58 from zabbix server:
snmpget -v2c -c xxxxx 10.2.0.12 ifHCOutOctets.58
IF-MIB::ifHCOutOctets.58 = Counter64: 140660672123
SNMP OID is OK
But in Zabbix 2.2.1 error message is generated:

3297:20140116:114717.601 item [pob16-s9703:ifHCOutOctets.XGigabitEthernet3-0-4] became not supported: Cannot find index "ifDescr" of the OID "ifHCOutOctets[index,ifDescr,XGigabitEthernet3/0/4]": Timeout while connecting to "10.2.0.11

Also I have a lot of similar problems with other OID:

3297:20140116:114717.602 item [pob16-s9703:ifHCOutOctets.Eth-Trunk0] became not supported: Cannot find index "ifDescr" of the OID "ifHCOutOctets[index,ifDescr,Eth-Trunk0]": Timeout while connecting to "10.2.0.12:161".
3297:20140116:114717.604 item [pob16-s9703:ifHCOutOctets.Office_Internet] became not supported: Cannot find index "ifAlias" of the OID "ifHCOutOctets[index,ifAlias,Office_Internet]": Timeout while connecting to "10.2.0.12:16
3297:20140116:114722.814 item [pob16-s9703:ifHCInOctets.GigabitEthernet1-0-6] became not supported: Cannot find index "ifDescr" of the OID "ifHCInOctets[index,ifDescr,GigabitEthernet1/0/6]": Timeout while connecting to "10.2.0.1
3297:20140116:114722.815 item [pob16-s9703:ifHCInOctets.XGigabitEthernet3-0-2] became not supported: Cannot find index "ifDescr" of the OID "ifHCInOctets[index,ifDescr,XGigabitEthernet3/0/2]": Timeout while connecting to "10.2.0.
3297:20140116:114722.826 item [pob16-s9703:ifHCOutOctets.GigabitEthernet1-0-12] became not supported: Cannot find index "ifDescr" of the OID "ifHCOutOctets[index,ifDescr,GigabitEthernet1/0/12]": Timeout while connecting to "10.2.0

At version 2.0.2 everything worked perfectly