Zabbix Agent should be extended to support native collection of profile-related data, for example:

Hostname
OS (Name, short and full details)
Software (list of installed packages)
MAC Addresses (comma delimited)
CPU info
HW Architecture
Device Hardware (list of PCI devices)
Device Chassis (if available)
Device Vendor (if available)
Device Model (if available)
Device Serial number (if available)

These items are supported under Linux already (ZBXNEXT-677).