I collect items where I do not need history, only triggers if it changed or too small. For example it can be equipment serial number, system uptime, admin state of interface and so on.
Using Zabbix 2.0.x I created items with 0 days history and 0 days trends and it works very good.
This scheme does not work with Zabbix 2.2.x.
Of course I can keep data for such items for a day and housekeeper will clear useless data, but due to large number of hosts and items I do not use housekeeper.